Taxane- and taxoid-protein compositions
AssigneeOncBioMune, L.L.C.
InventorsJonathan F. Head, Robert L. Elliott
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Abstract
Compositions comprising a taxane or taxoid, such as paclitaxel, and a protein, such as albumin or a metal-transferrin, such as gallium-transferrin, can be prepared by combining an aqueous protein solution with a second solution containing the taxane or taxoid, a non-ionic surfactant, and an alcohol; adjusting the pH of the combined solutions to between about 7.9 and about 8.3; and purifying the pH-adjusted solution to remove solutes having a molecular weight less than 10,000 Da. Such compositions can be prepared that are substantially free of non-ionic surfactants, such as Cremophor EL, and are useful in the treatment of cancers, such as breast cancer.
Claims8
A composition comprising A) a complex consisting of (i) a metal-transferrin;
- and (ii) a taxane or taxoid that inhibits mitosis;
- and B) a pharmaceutically acceptable diluent,
- wherein the taxane or taxoid either (a) is bonded with the metal-transferrin via a direct bond between the taxane or taxoid and the metal-transferrin;
- or (b) forms a non-covalent complex with the metal-transferrin;
- the transferrin of the metal-transferrin is human transferrin, bovine transferrin, serotranferrin, lactotransferrin, ovotransferrin, or melanotransferrin, and
- the composition substantially lacks solutes having a molecular weight less than 10,000 Da.
Dependencies are inferred from the claim text.