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US 9,327,056 B2Granted
Bone replacement materials
AssigneeWashington State University
InventorsAmit Bandyopadhyay, Susmita Bose
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AssigneeWashington State University
InventorsAmit Bandyopadhyay, Susmita Bose
Estimating the term…
Provided are devices for bone tissue engineering, comprising a metal or metal-based composite member comprising an interior macroporous structure with porosity varying from 0-90% (v), the member comprising a surface region having a surface pore size, porosity, and composition designed to encourage cell growth and adhesion thereon, to provide a device engineered for a particular recipient subject. Engineered devices may further comprises a gradient of pore size, porosity, and material composition extending from the surface region throughout the interior of the device, wherein the gradient transition is continuous, discontinuous or seamless to promote cell in-growth. Additional aspects provide methods for bone tissue engineering, comprising use of a metal or metal-based composite member comprising an interior porous structure, wherein the pore size, porosity and material composition is selected to provide a device having an optimal density and/or elastic modulus and/or compression strength for a specific recipient. Fabrication methods are provided.
A device for bone tissue engineering, comprising a member of a biocompatible metal or metal-based composite, the member having an exterior surface, an interior voided core area of void fraction between 30 and 90% by volume, and a porous exterior surface region configured to encourage cell growth and adhesion thereon, wherein an increasing porosity vol % gradient extends from the exterior surface, through the porous exterior surface region, and throughout the interior voided core area, and wherein at least one of the pore size, porosity and material composition is configured to provide a device having a target density, elastic modulus or compression strength for a specific recipient to provide an implantable device suitable for bone tissue engineering in a recipient subject.
A recipient-optimized device for bone tissue engineering, comprising a member of a biocompatible metal or metal-based composite, the member having an exterior surface, an interior voided core area of void fraction between 30 and 90% by volume, and a porous exterior surface region, wherein an increasing porosity vol % gradient extends from the exterior surface, through the porous exterior surface region, and throughout the interior voided core area, and wherein at least one of the pore size, porosity and material composition is configured to provide a device having a target density for a specific recipient.
A recipient-optimized device for bone tissue engineering, comprising a member of a biocompatible metal or metal-based composite, the member having an exterior surface, an interior voided core area of void fraction between 30 and 90% by volume, and a porous exterior surface region, wherein an increasing porosity vol % gradient extends from the exterior surface, through the porous exterior surface region, and throughout the interior voided core area, and wherein at least one of the pore size, porosity and material composition is selected to provide a device having a target elastic modulus for a specific recipient.
A recipient-optimized device for bone tissue engineering, comprising a member of a biocompatible metal or metal-based composite, the member having an exterior surface, an interior voided core area of void fraction between 30 and 90% by volume, and a porous exterior surface region, wherein an increasing porosity vol % gradient extends from the exterior surface, through the porous exterior surface region, and throughout the interior voided core area, and wherein at least one of the pore size, porosity and material composition is selected to provide a device having a target compression strength for a specific recipient.
A device for bone tissue engineering, comprising:
A device for bone tissue engineering, comprising:
Dependencies are inferred from the claim text.