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US 9,322,067 B2Granted
Molecular profiling of tumors
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
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Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
Claims20
A method of identifying at least one candidate treatment for a subject in need of treatment for a cancer, comprising:
- (a) performing an immunohistochemistry (IHC) analysis on a sample from the subject on a plurality of IHC molecular targets, wherein the plurality of IHC molecular targets comprises at least TOP1, TYMS, MGMT, PTEN, and HER2;
- (b) performing an in situ hybridization (ISH) analysis on the sample on a plurality of ISH molecular targets, wherein the plurality of ISH molecular targets comprises at least HER2 and cMET;
- (c) performing DNA sequencing analysis on the sample on a plurality of sequencing molecular targets, wherein the plurality of sequencing molecular targets comprises at least PIK3CA, KRAS, and BRAF;
- (d) using a computer to access a rules database comprising at least one biomarker-drug association rules for each of the molecular targets analyzed in steps (a)-(c);
- and
- (e) producing a computer generated report based on a comparison of analysis in steps (a)-(c) against the rules assessed in step (d), wherein the report identifies the at least one candidate treatment.
3 more elements
Dependencies are inferred from the claim text.