System and method for diagnosis and treatment
AssigneePop Test Oncology Limited Liability Company
InventorsRandice Lisa Altschul, Neil David Theise, Myron Rapkin, Rebecca O'Brien
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Abstract
This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.
Claims8
A method for treating neoplasia characterized by expression of a glucocorticoid receptor, in a patient in need of such treatment, comprising:
- administering to said patient therapeutically effective amounts of each of:
- at least one neoplasia-treating agent selected from the group consisting of taxanes, and combinations thereof;
- and
- a GCR (glucocorticoid receptor) antagonist selected from the group consisting of ORG 34517, 11-(substituted phenyl)-estra-4,9-diene derivatives, and 11-(substituted phenyl)-estra-4,9-diene derivatives of formula I
- wherein A is a residue of a 5- or 6-membered ring containing 2 heteroatoms which are not connected to each other and independently selected from O and S, the ring being optionally substituted with one or more halogen atoms, or A is a residue of a 5- or 6-membered ring wherein no double C—C bonds are present, containing 1 heteroatom selected from O and S, which heteroatom is connected to the phenyl group at the position indicated with an asterisk, the ring being optionally substituted with one or more halogen atoms;
- R1 is H or 1-oxo(1-4C)alkyl;
- R2 is H, (1-8C)alkyl, halogen or CF3;
- X is selected from (H,OH), O, and NOH;
- and the interrupted line represents an optional bond,
- wherein the neoplasia is selected from the group consisting of hepatocellular carcinoma, breast cancer, prostate cancer, lung cancer, and ovarian cancer.
Dependencies are inferred from the claim text.