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US 9,316,654 B2Granted
TAZ/WWTR1 for diagnosis and treatment of cancer
AssigneeAgency for Science, Technology and Research (A*Star)
InventorsWanjin Hong, Siew Wee Chan
Life of this patent
Estimating the term…
Abstract
We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of TAZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of TAZ in the cell.
Claims1
A method for treating cancer, comprising:
- detecting upregulation of expression, amount or activity of TAZ/WWTR1 in a cancer cell obtained from a subject as compared to the expression, amount or activity of TAZ/WWTR1 in a control cell known to be non-cancerous, wherein said detecting comprises contacting said cell with an antibody or antigen-binding fragment thereof that specifically binds TAZ/WWTR1;
- and
- administering an anti-TAZ antibody agent to the subject that inhibits TAZ/WWTR1 expression or activity.
Dependencies are inferred from the claim text.