Detection and removal of misfolded proteins/peptides
AssigneeOxprotect GmbH
InventorsBeate Kehrel, Martin Brodde
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AssigneeOxprotect GmbH
InventorsBeate Kehrel, Martin Brodde
Estimating the term…
The invention concerns the field of detecting and quantifying misfolded proteins/peptides. In particular the detection and quantification of misfolded proteins/peptides in body fluids, on cell surfaces of humans and mammals, the detection of misfolded proteins/peptides in reagents to be tested for scientific research and/or diagnostic use and in pharmaceutical medication or their additives and it concerns as well the removal of misfolded proteins/peptides from reagents to be tested for scientific research and/or for diagnostic purposes and from pharmaceutical medication or their additives. Furthermore the invention includes substances to identify and methods to detect bio-films, a method to examine hemocompatibility of materials and a method to optimize therapeutical products, and to provide reagents microorganisms to charge with for more reliable diagnostics and quality control of biopharmaceuticals and identification substances for the screening for preliminary stages of amyloids that can be used for technical purposes.
A binding substance selected from proteins or peptides comprising the amino acid sequence HWRR (SEQ ID NO:
A method for binding misfolded proteins or peptides in a sample comprising contacting a sample containing said misfolded proteins or peptides with a binding substance capable of binding to said misfolded proteins or peptides, wherein the binding substance is selected from proteins or peptides comprising the amino acid sequence HWRR (SEQ ID NO:
A method of treating disease linked to misfolded proteins or peptides in a subject comprising depleting or removing misfolded proteins or peptides from a body fluid of the subject by contacting the body fluid with a binding substance capable of binding to said misfolded proteins or peptides, wherein the binding substance is selected from proteins or peptides comprising the amino acid sequence HWRR (SEQ ID NO:
Dependencies are inferred from the claim text.