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US 9,316,647 B2Granted
Aptamers and diagnostic methods for detecting the EGF receptor
AssigneeSomaLogic, Inc.
InventorsMalti P. Nikrad, Bharat Nathu Gawande
Life of this patent
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Abstract
The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers.
Claims10
An aptamer comprising the nucleotide sequence:
- XGANNGNNYGANNCNN (SEQ ID NO:
- 55);
- wherein
- X is a G, C or A;
- Y is a G or A;
- and
- N is, independently a 5-position modified 2′-deoxyuridine selected from the group consisting of 5-(N-benzylcarboxyamide)-2′-deoxyuracilyl, 5-(N-isobutylcarboxyamide)-2′-deoxyuridine, 5-(N-tryptaminocarboxyamide)-2′-deoxyuridine, 5-(N-[1-(3-trimethylamonium) propyl]carboxyamide)-2′-deoxyuridine chloride, 5-(N-naphthylmethylcarboxamide)-2′-deoxyuridine, and 5-(N-[1-(2,3-dihydroxypropyl)]carboxyamide)-2′-deoxyuridine.
4 more elements
An aptamer that binds to EGFR comprising a nucleotide sequence selected from the group consisting of SEQ. ID. NOS:
- 1-54.
An aptamer that binds EGFR comprising a nucleotide sequence having at least 90% identity to anyone of the nucleotide sequences of SEQ ID NOs:
- 1-54.
Dependencies are inferred from the claim text.