Use of gelsolin to diagnose and treat inflammatory diseases
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsThomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski
Life of this patent
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Abstract
The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
Claims18
A method for treating a subject having an inflammatory disease comprising:
- administering to a subject in need of such a treatment an effective amount of plasma gelsolin to treat the subject, wherein the inflammatory disease is rheumatoid arthritis or inflammatory bowel disease.
A method for treating a subject having an inflammatory disease comprising:
- administering to a subject in need of such a treatment an effective amount of plasma gelsolin to raise the level of gelsolin in the subject above a predetermined value, wherein the inflammatory disease is rheumatoid arthritis or inflammatory bowel disease.
A method for treating a subject to reduce the risk of an inflammatory disease comprising:
- (i) selecting a subject who has a below-normal level of gelsolin and
- (ii) administering to the subject plasma gelsolin and/or a second agent in an effective amount to reduce the risk of the subject developing the inflammatory disease, wherein the inflammatory disease is rheumatoid arthritis or inflammatory bowel disease.
A method for treating a subject to reduce the risk of an inflammatory disease comprising:
- (i) selecting a subject who has a below-normal level of gelsolin and
- (ii) administering to the subject plasma gelsolin and/or a second agent in an effective amount to raise the level of gelsolin in the subject above a predetermined value, wherein the inflammatory disease is rheumatoid arthritis or inflammatory bowel disease.
Dependencies are inferred from the claim text.