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US 9,315,865 B2Granted
Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene, and use of them
AssigneeInternational Institute of Cancer Immunology, Inc.
InventorHaruo Sugiyama
Life of this patent
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Abstract
Disclosed are: a nucleotide sequence and an amino acid sequence for CDR3 region of T-cell receptor (TCR) gene of WT1-specific cytotoxic T-cell (CTL) for WT1 protein; a method for the detection or treatment of cancer using the nucleotide sequence or the amino acid sequence; and a chip, a primer set, a kit, an apparatus and the like for use in the detection of cancer, each of which comprises the nucleotide sequence or the amino acid sequence.
Claims2
A synthesized cDNA, comprising:
- (1) a nucleotide sequence encoding the entire amino acid sequence of a complementarity determining region 3 (CDR3) of a vβ chain of a T-cell receptor (TCR) of a WT1-specific HLA-A*2402-positive cytotoxic T-cell (CTL), wherein the nucleotide sequence is selected from the group consisting of SEQ ID NOs:
- 1-200, or
- (2) the nucleotide sequence that is complementary to the full length of the nucleotide sequence of (1),
- wherein the cDNA further comprises a label attached to the cDNA, said label selected from fluorescent labels, radioactive labels, enzyme labels, and chromophore labels.
1 more element
Dependencies are inferred from the claim text.