Yeast cells expressing an exogenous cellulosome and methods of using the same

A transformed yeast host cell comprising:

• a) at least one heterologous polynucleotide comprising a nucleic acid which encodes an endogluconase;
• b) at least one heterologous polynucleotide comprising a nucleic acid which encodes a (β-glucosidase;
• c) at least one heterologous polynucleotide comprising a nucleic acid which encodes a first cellobiohydrolase;
• and,
• d) at least one heterologous polynucleotide comprising a nucleic acid which encodes a second cellobiohydrolase different from the first cellobiohydrolase;
• wherein at least one of the endoglucanase, (β-glucosidase, first or second cellobiohydrolase is fused to a dockerin domain;
• and
• said transformed yeast host cell further comprising:
• e) a nucleic acid which encodes an exogenous scaffoldin polypeptide;
• wherein the scaffoldin polypeptide contains at least one cohesin domain.