Subgroup B recombinant human adenovirus vector, and methods for constructing and for using the same
AssigneeBeijing Bio-Targeting Therapeutics Technology Inc.
InventorsYaohe Wang, Guozhong Jiang, Hanshi Wong, Fengyu Cao, Nick Lemoine
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Abstract
A method for constructing a subgroup B recombinant human adenovirus vector Ad11-5EP. The method includes substituting a 365 bp fragment including an enhancer and a promoter of an upstream coding sequence of Ad5 E1A for a corresponding region of a serotype Ad11 of the subgroup B human adenovirus vector by homologous recombination to construct the subgroup B recombinant human adenovirus vector Ad11-5EP. A subgroup B recombinant human adenovirus vector Ad11-5EP constructed by the method and the use thereof for treatment of tumors are also provided.
Claims3
A method for constructing a subgroup B recombinant human adenovirus vector Ad11-5EP (SEQ ID NO:
- 1), the method comprising substituting a 365 by fragment comprising an enhancer and a promoter of an upstream coding sequence of Ad5 E1A (SEQ ID NO:
- 2) for a corresponding region of a serotype Ad11 (SEQ ID NO:
- 3) of the subgroup B human adenovirus vector by homologous recombination to construct the subgroup B recombinant human adenovirus vector Ad11-5EP (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.