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US 9,315,814 B2Granted
Immunostimulatory oligodeoxynucleotides
AssigneeIntervet Inc.
InventorsCarla Christina Schrier, Simon Ilg
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Abstract
The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease and to methods for the detection of such oligodeoxynucleotides.
Claims13
An immunostimulatory non-methylated oligodeoxynucleotide having the general formula
- 5′ [G]x {T C G T C G}n T C G [G]z3′
- wherein
- x=3-20;
- z=0-10;
- n=4-18;
- or a pharmaceutically acceptable salt thereof;
- wherein when said immunostimulatory non-methylated oligodeoxynucleotide is administered to a chicken, it stimulates the initiation of signaling cascades leading to the activation of transcription factors that in turn result in the expression of inflammatory cytokines.
4 more elements
Dependencies are inferred from the claim text.