Methods for modulating kallikrein (KLKB1) expression
AssigneeIonis Pharmaceuticals, Inc.
InventorsGourab Bhattacharjee, Alexey Revenko, Robert A. MacLeod
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Abstract
Disclosed herein are methods for decreasing kallikrein and treating or preventing inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to kallikrein include hereditary angioedema (HAE). Methods for inhibiting kallikrein can also be used as a prophylactic treatment to prevent individuals at risk for developing an inflammatory condition, such as, hereditary angioedema.
Claims22
A method comprising, prophylactically treating hereditary angioedema (HAE) in an animal identified as having HAE by administering to the animal a therapeutically effective amount of a compound comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides, wherein the modified oligonucleotide is at least 90% complementary to a KLKB1 nucleic acid.
Dependencies are inferred from the claim text.