Oligonucleotide derivative, oligonucleotide derivative-containing pharmaceutical composition for treatment and pharmaceutical composition for diagnosis, and oligonucleotide derivative for regulation of miRNA function
AssigneeNational University Corporation Hokkaido University
InventorsAkira Matsuda, Mayumi Takahashi
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Abstract
An oligonucleotide derivative comprises repeating structural units represented by the following general formula (wherein B represents adenine, guanine, cytosine, or uracil; X represents a sulfur atom or an oxygen atom; n represents an integer of 6 to 60; and B and X are independently represented in each of the repeating structural units), wherein X is a sulfur atom in at least one of the repeating structural units represented by the general formula:
Claims7
A method for treatment comprising administering an oligonucleotide derivative comprising repeating structural units represented by general formula:
- wherein B represents adenine, guanine, cytosine, or uracil;
- X represents a sulfur atom in all of the repeating structural units represented by the general formula;
- n represents an integer of 6 to 60;
- and B and X are independently represented in each of the repeating structural units, wherein the oliqonucleotide derivative comprises a sequence complementary to an entire sequence or a partial sequence of a miRNA.
A method for diagnosis comprising administering an oligonucleotide derivative comprising repeating structural units represented by general formula:
- wherein B represents adenine, guanine, cytosine, or uracil;
- X represents a sulfur atom in all of the repeating structural units represented by the general formula;
- n represents an integer of 6 to 60;
- and B and X are independently represented in each of the repeating structural units, wherein the oligonucleotide derivative comprises a sequence complementary to an entire sequence or a partial sequence of a miRNA.
A method for inhibiting miRNA function comprising administering an oligonucleotide derivative comprising repeating structural units represented by general formula:
- wherein B represents adenine, guanine, cytosine, or uracil;
- X represents a sulfur atom in all of the repeating structural units represented by the general formula;
- n represents an integer of 6 to 60;
- and B and X are independently represented in each of the repeating structural units, wherein the oliqonucleotide derivative comprises a sequence complementary to an entire sequence or a partial sequence of a miRNA.
Dependencies are inferred from the claim text.