Differentially expressed microRNA molecules for the treatment and diagnosis of cancer
AssigneeCity of Hope
InventorsYanhong Shi, Ming-Fei Lang, Chunnian Zhao
Life of this patent
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Abstract
A significant challenge in cancer research field is to define molecular features that distinguish cancer stem cells from normal stem cells. In this study, microRNA (miRNA) expression profiles in human glioblastoma stem cells were compared to that of normal neural stem cells using combined microarray and deep sequencing analyzes. These studies led to the identification of several miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. Characterizing the role of these miRNAs in glioblastoma stem cells is important for the development of miRNA-based therapies that specifically target tumor stem cells, but spare normal stem cells.
Claims4
A method of treating a glioblastoma comprising:
- administering a therapeutically effective amount of a pharmaceutical composition to a subject having the glioblastoma,
- wherein the pharmaceutical composition comprises at least one miRNA molecule that is down regulated in a stem cell of the glioblastoma compared to a normal neural stem cell, a vector capable of expressing said at least one miRNA molecule in a glioblastoma stem cell, or a combination thereof,
- and wherein the at least one miRNA molecule that is down regulated in the glioblastoma stem cell compared to a normal neural stem cell is a miR-874 molecule.
Dependencies are inferred from the claim text.