Process for preparing phosphate compound bearing isotope
AssigneeBonac Corporation
InventorsTomohiro Hamasaki, Tadaaki Ohgi
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Abstract
The present invention provides a process for preparing an isotope-containing phosphate compound easily. The process for preparing an isotope-containing phosphate compound according to the present invention includes the step of: oxidizing a trivalent phosphorus compound with an oxidizing agent containing an isotope to synthesize a pentavalent phosphate compound to which the isotope has been introduced. The present invention preferably is applied to the synthesis of nucleic acids such as DNA and RNA, for example. The isotope preferably is a stable isotope. The oxidizing agent preferably is H218O, 3H-1,2-benzodithiol 3-one 1,1-dioxide having 34S, or a diisopropylethylamine-borane complex having 10B, for example.
Claims13
A process for preparing an isotope-containing phosphate compound, the process comprising the step of:
- oxidizing a trivalent phosphorus compound with an oxidizing agent containing an isotope to synthesize a pentavalent phosphate compound to which the isotope has been introduced,
- wherein
- the oxidizing agent containing an isotope is (a) I2/water containing 17O or 18O or (b) a peroxide containing 17O or 18O, and
- the trivalent phosphorus compound is a compound that includes the structure
Dependencies are inferred from the claim text.