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US 9,315,778 B2Granted
Engineered extracellular matrices control stem cell behavior
AssigneePurdue Research Foundation
InventorsSherry L. Voytik-Harbin, Beverly Z. Waisner
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Abstract
A composition for culturing stem cells is provided. The composition comprises an engineered purified collagen based matrix that has been formed under controlled conditions to have the desired microstructure and mechanical properties. The engineered purified collagen based matrix compositions of the present invention can be used alone or in combination with cells as a tissue graft construct to enhance the repair of damaged or diseased tissues.
Claims25
A tissue graft composition, said composition comprising
- a synthetic collagen-based matrix comprising collagen fibrils, wherein the matrix has an elastic or linear modulus of about 0.5 kPa to about 40 kPa;
- and
- a population of mesenchymal stem cells,
- wherein the matrix is prepared by a process comprising the step of controlling the elastic or linear modulus to make the stem cells adipogenic or osteogenic.
1 more element
Dependencies are inferred from the claim text.