Method and carrier complexes for delivering molecules to cells
AssigneeCornell Research Foundation, Inc.
InventorsHazel Szeto, Kesheng Zhao, Hugh Robertson, Alex V. Birk
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Abstract
The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
Claims20
A method for delivering a molecule to a cell, the method comprising contacting the cell with a carrier complex, wherein the carrier complex comprises the molecule conjugated to an aromatic cationic peptide, wherein the aromatic cationic peptide is selected from the group consisting of:
- Tyr-D-Arg-Phe-Lys-NH2 (DALDA), 2′,6′-Dmt-D-Arg-Phe-Lys-NH2 (Dmt1-DALDA), Phe-D-Arg-Phe-Lys-NH2 (Phe1-DALDA), D-Arg-2′,6′-Dmt-Lys-Phe-NH2, and 2′,6′-Dmp-D-Arg-Phe-Lys-NH2 (Dmp1-DALDA);
- and wherein the molecule is a lipid.
Dependencies are inferred from the claim text.