Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
AssigneesNational University of Singapore, DSO National Laboratories
InventorsPaul Anthony Macary, Conrad En Zuo Chan, Brendon John Hanson, Markus R. Wenk
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Abstract
Described herein are antigen binding proteins that bind to pathogenic mycobacteria-derived Mannose-Capped Lipoarabinomannan (ManLAM) and methods and kits for using and making the antigen binding proteins. Also described herein are antigen binding proteins that bind to the alpha 1-2 linkage mannose caps of ManLAM, antigen binding proteins that bind to a mannose cap with up to three alpha 1-2 linked mannose residues, and antigen binding proteins that bind to LAM with a mannose sugar capping motif.
Claims13
An isolated antigen binding protein (ABP) or fragment thereof that specifically binds to an alpha 1-2 linkage mannose cap of Mannose-Capped Lipoarabinomannan (ManLAM), wherein the ABP or fragment thereof is a recombinant chimeric ABP and comprises SEQ ID NOs:
- 7, 8, 9, 27, a sequence having at least 71.4% identity to SEQ ID NO:28, and a sequence having at least 94.7% identity to SEQ ID NO:29.
An isolated antigen binding protein (ABP) or fragment thereof that specifically binds to an alpha 1-2 linkage mannose cap of Mannose-Capped Lipoarabinomannan (ManLAM), wherein the ABP or fragment thereof is a recombinant chimeric ABP and comprises a polypeptide having an amino acid sequence at least 97.4% identical to SEQ ID NO:
- 15 and an amino acid sequence at least 96.4% identical to SEQ ID NO:
- 18.
Dependencies are inferred from the claim text.