Cosmetic or pharmaceutical compositions comprising metalloproteinase inhibitors
AssigneeLipotec, S.A.
InventorsCristina Carreño Serraïma, Wim Van Den Nest, Juan Cebri{dot over (a)}n Puche, Nuria Almiñana Domenech, Antonio Ferrer Montiel, Nuria Garcia Sanz
Life of this patent
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Abstract
Peptides of general formula (I): R1AA1-AA2-AA3-AA4-R2 stereoisomers thereof, mixtures thereof or the cosmetically or pharmaceutically acceptable salts thereof, a method for obtaining them, cosmetic or pharmaceutical compositions containing them, and their use for the treatment and/or care of those conditions, disorders and/or pathologies of the skin, mucosae and/or scalp resulting from matrix metalloproteinases (MMP) overexpression or an increase in the MMP activity.
Claims20
A peptide of general formula (I)
- R1-AA1-AA2-AA3-AA4-R2 (I)
- stereoisomers thereof, mixtures of stereoisomers thereof, or the cosmetically or pharmaceutically acceptable salts thereof, wherein:
- AA1 is -Arg-;
- AA2 is selected from the group consisting of -His- and -Asn-;
- AA3 is selected from the group consisting of -His- and -Arg-;
- AA4 is -Cit-;
- each of AA1, AA2, AA3, and AA4 is independently selected from L- and D-configurations and mixtures thereof;
- R1 is selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic groups, substituted or non-substituted alicyclyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heteroarylalkyl, substituted or non-substituted aryl, substituted or non-substituted aralkyl, and R5—CO—;
- and
- R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3;
- wherein R3 and R4 are independently selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic groups, substituted or non-substituted alicyclyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heteroarylalkyl, substituted or non-substituted aryl and substituted or non-substituted aralkyl,
- wherein R5 is selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic groups, substituted or non-substituted alicyclyl, substituted or non-substituted aryl, substituted or non-substituted aralkyl, substituted or non-substituted heterocyclyl and substituted or non-substituted heteroarylalkyl.
A cosmetic or pharmaceutical method for the treatment and/or care of skin, mucosae and/or scalp, comprising the administration of an effective amount of at least one peptide of general formula (I)
- R1-AA1-AA2-AA3-AA4-R2 (I),
- stereoisomers thereof, mixtures of stereoisomers thereof, or the cosmetically or pharmaceutically acceptable salts thereof, to the skin, mucosae and/or scalp, wherein said treatment and/or care includes inhibiting at least one skin, mucosae and/or scalp matrix metalloprotease selected from the group consisting of human MMP-1, MMP-2, MMP-3 and MMP-9,
- wherein:
- AA1 is -Arg-;
- AA2 is selected from the group consisting of -His- and -Asn-;
- AA3 is selected from the group consisting of -His- and -Arg-;
- AA4 is -Cit-;
- each of AA1, AA2, AA3, and AA4 is independently selected from L- and D-configurations and mixtures thereof;
- R1 is selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic groups, substituted or non-substituted alicyclyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heteroarylalkyl, substituted or non-substituted aryl, substituted or non-substituted aralkyl, and R5—CO—;
- R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3;
- wherein R3 and R4 are independently selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic groups, substituted or non-substituted alicyclyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heteroarylalkyl, substituted or non-substituted aryl and substituted or non-substituted aralkyl;
- and
- R5 is selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic groups, substituted or non-substituted alicyclyl, substituted or non-substituted aryl, substituted or non-substituted aralkyl, substituted or non-substituted heterocyclyl, and substituted or non-substituted heteroarylalkyl.
Dependencies are inferred from the claim text.