Compositions comprising the NC2 domain of collagen IX and methods of using same
AssigneeShriners Hospital For Children
InventorsHans Peter Bachinger, Sergey P. Budko
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Abstract
The present invention relates to the newly identified timerization initiating and stagger determining capacity of the NC2 domain of collagen IX. The invention further relates to a hexavalent molecular building block wherein the linkage of additional moieties to the amino and carboxyl terminals of monomers comprising the NC2 domain of collagen IX promotes the directed association of those moieties via the trimerization initiating and stagger determining capacity of the NC2 domain of collagen IX.
Claims11
A Collagen IX NC2 domain-conjugate composition comprising a heterologous moiety operably linked to a Collagen IX NC2 domain consisting of the peptide sequence of SEQ ID 19, SEQ ID 20, or SEQ ID 21.
Dependencies are inferred from the claim text.