Beta sheet tapes ribbons in tissue engineering
AssigneeUniversity of Leeds
InventorsNeville Boden, Amalia Aggeli, Eileen Ingham, Jennifer Kirkham
Life of this patent
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Abstract
There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
Claims17
A pair of self assembling complementary polypeptides (SACPs) that form tapes, ribbons, fibrils or fibres in a β-sheet tape-like substructure when a first monomeric peptide is contacted or mixed with its complementary monomeric peptide, and wherein the SACPs comprise P11-28/29 (SEQ ID NOs:
- 6 and 7).
A composition, comprising:
- tapes, ribbons, fibrils or fibres, wherein each of the tapes, ribbons, fibrils or fibres has an antiparallel arrangement of SACPs in a β-sheet tape-like substructure, wherein the SACPs comprise P11-28/29 (SEQ ID NOs:
- 6 and 7).
Dependencies are inferred from the claim text.