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US 9,315,548 B2Granted
Peptoid oligomers, pharmaceutical compositions and methods of using the same
AssigneeNew York University
InventorsKent Kirshenbaum, Sung Bin Shin
Life of this patent
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Abstract
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present cyclic and linear peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.
Claims24
A peptoid oligomer according to formula lb:
- wherein
- each R1 is independently R1a, R1b, or R1c;
- each R2 is independently hydrogen, or substituted or unsubstituted alkyl;
- or each R1 and R2 are joined together to form a 4-7 membered heterocyclic ring;
- each R1a is independently unsubstituted alkyl, or alkyl substituted with halo, hydroxy, amino, nitro, or alkoxy;
- each R1b is independently aminoalkyl, guanidinoalkyl (H2N—C(═NH)—NH-alkyl), or N-containing heteroarylalkyl, and each R1b is unsubstituted or substituted with one or more F;
- each R1c is independently substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted diarylalkyl;
- and n is an integer between 4 and 20;
- provided that at least one of R1s is R1b;
- a pharmaceutically acceptable salt, a stereoisomer, an isotopic variant, or a tautomer thereof.
7 more elements
Dependencies are inferred from the claim text.