Back to results
US 9,315,547 B2Granted
Nuclear targeting sequences
AssigneeYeda Research and Development Co. Ltd.
InventorsRony Seger, Dana Chuderland
Life of this patent
Estimating the term…
Abstract
Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.
Claims5
A method of treating a hyperproliferative disease in a subject, the method comprising administering to the subject a therapeutically effective amount of an isolated peptide into the subject, wherein said isolated peptide is less than 20 amino acids and comprises an amino acid sequence at least 70% homologous to the sequence as set forth by:
- (SEQ ID NO:
- 38)
- L D Q L N H I L G I L G X1 P X1 Q E D;
- wherein X1 is selected from the group consisting of Thr, Asp and Glu, the isolated peptide being capable of preventing ERK nuclear translocation, thereby treating the hyperproliferative disease.
1 more element
Dependencies are inferred from the claim text.