Back to results
US 9,315,540 B2Granted
Process for the preparation of fulvestrant
AssigneeIntas Pharmaceuticals Ltd.
InventorsMettilda Lourdusamy, Ioan Iosif Radu, Brijesh Dinkarrai Desai, Pramod Bhagvanjibhai Pansuriya, Sanjay Jagdish Desai
Life of this patent
Estimating the term…
Abstract
The present invention relates to an improved process for the preparation of Fulvestrant (I). Also, provided is novel intermediate of Fulvestrant and a process for the preparation of the same.
Claims17
A process for preparing Fulvestrant comprising:
- (a) oxidizing the hydroxy group of FUL-Ia
- by using the oxidizing agent Dess-Martin Periodinane to obtain FUL-I
- (b) alkylating FUL-I with 1,9-dibromononane in a solvent in presence of a base to obtain the alkylated derivative of formula FUL-II
- (c) reacting FUL-II with 4,4,5,5,5-pentafluoropentane phenyl thioester in a solvent in presence of a base to obtain the compound of formula FUL-IV
- (d) converting the compound of formula FUL-IV to Fulvestrant.
2 more elements
A compound of formula FUL-II,
Dependencies are inferred from the claim text.