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US 9,315,534 B2Granted
Radiologic agents for monitoring alzheimer's disease progression and Evaluating a Response to Therapy and processes for the preparation of such agents
AssigneeBoard of Regents of the University of Nebraska
InventorsZbigniew P. Kortylewicz, Janina Baranowska-Kortylewicz
Life of this patent
Estimating the term…
Abstract
Disclosed are certain cycloSalingenyl pyrimidine nucleoside monophosphates comprising positron emitters or gamma-emitting radiohalides, uses thereof for monitoring Alzheimer's disease progression and evaluating response to therapy and process for their preparation.
Claims11
A compound of the formula:
- wherein R represents a substituted or unsubstituted, straight or branched chain, saturated or unsaturated hydrocarbyl (C1-C15) group, radioactive halogen, non-radioactive halogen;
- Ra represents radioactive halogen, non-radioactive halogen, hydroxyl, one of R and Ra being radioactive halogen;
- X represents hydrogen, non-radioactive halogen, radioactive halogen;
- Y represents hydrogen, a straight or branched chain, substituted or unsubstituted, saturated or unsaturated hydrocarbyl (C1-C4) group, and 11C-containing analogues of said hydrocarbyl group;
- and
- Z represents hydrogen, straight or branched chain, substituted or unsubstituted saturated or unsaturated hydrocarbyl (C1-C4) group, and 11C-containing analogues of said hydrocarbyl group.
3 more elements
Dependencies are inferred from the claim text.