Antibacterial compounds

A compound of formula (I)

• wherein
• M is moiety of formula
• the bond is a single bond or a double bond,
• wherein when is a double bond, then X is C(R4);
• and when is a single bond, then X is N(R4) or C(R3)(R4);
• R1 is hydrogen, C1-4alkyl or halo;
• R2 is hydrogen, C1-4alkyl or halo;
• Rx is selected from the group of moieties of formulae (i), (ii) and (iii),
• wherein
• Xx is C(H), C(Ryy) or N;
• Ryy is selected from the group consisting of hydrogen, halo, —CN, A1 and B1;
• wherein each of said A1 and B1 is optionally and independently substituted by one or more fluoro atoms, and said A1 is —O—C1-6 alkyl, and said B1 is C1-6 alkyl;
• Ry1 is one to three optional substituents each independently selected from hydrogen, halo, —CN, A1 or B1;
• each Ry2 and Ry3 independently is hydrogen or -Q1-R5;
• each Q1 independently is a direct bond or —C(O)—;
• each R5 is hydrogen, A2, B2, A3 or B3;
• wherein each of said A2 and B2 is optionally and independently substituted by at least one of ═O and Q2, said A2 is C1-6 alkyl, said B2 is heterocycloalkyl, and wherein each of said A3 and B3 is optionally and independently substituted by at least one of Q3 substituents, said A3 is aryl and said B3 is heteroaryl;
• Q2 is selected from the group consisting of halo, —CN, A4, B4 and B5;
• wherein said A4 is optionally substituted by at least one fluoro, said A4 is —OC1-6 alkyl, and each of said B4 and B5 is optionally and independently substituted by one or more substituents selected from the group consisting of halo, —CN, optionally fluoro-substituted C1-3 alkyl and optionally fluoro-substituted —OC1-3 alkyl, said B4 is aryl, and said B5 is heteroaryl;
• Q3 is selected from the group consisting of halo, —CN, A5 and B6;
• wherein each of said A5 and B6 is optionally and independently substituted by at least one fluoro, and said A5 is —O—C1-6 alkyl and said B6 is C1-6 alkyl;
• wherein
• Xx1 is C(H) or N;
• Z1 is —X1—O—X1a—, —X2—N(Rz3)—X2a—, or —X3—S—X3a—;
• each of X1, X2 and X3 independently is a direct bond, —C(O)—, or —C(Rz4)(Rz5)—;
• each of X1a, X2a and X3a independently is a direct bond or —V1—C(Rz1)(Rz2)—;
• V1 is a direct bond or —C(O)—;
• each of Rz1, Rz2, Rz3, Rz4 and Rz5 independently is selected from the group consisting of hydrogen, A6- and B7, wherein said A6 is optionally substituted by at least one of ═O and halo, said A6 is C1-6 alkyl, said B7 is optionally substituted by at least one of ═O, halo and C1-3 alkyl, and said B7 is heterocycloalkyl;
• and
• wherein
• Xx1 is C(H) or N;
• Z2 is —C(Rz6)(Rz7)— or —C(O)—;
• Z3 is —CH2 and moiety (iii) is moiety (iii.1)
• or a bond and moiety (iii) is moiety (iii.2)
• A is a 5- or 6-membered ring optionally containing one, two or three double bonds and optionally containing an additional one to three heteroatoms, wherein each one of said heteroatoms is N or O, wherein said A is optionally substituted by one or more substituents each independently selected from ═O and Rz8;
• each Rz6, Rz7 and Rz8 independently is hydrogen or A7, wherein said A7 is optionally substituted by at least one substituent selected from the group consisting of ═O, —OC1-4 alkyl and halo and said A7 is C1-6 alkyl;
• each R3 independently is hydrogen, halo, —OR10 or A8 wherein said A8 is optionally substituted by at least one halo and said A8 is C1-6 alkyl;
• each R4 independently is hydrogen, halo or -T1-R20;
• wherein each T1 independently is a bond, —O—, —C(O)—, —C(O)—O—, —O—C(O)—, —C(O)—N(R21)— or —S(O)n1— wherein n1 is 0, 1 or 2, and R21 is hydrogen or C1-6 alkyl;
• each R10 and each R20 independently is A9, B8 or B9, wherein said A9 is optionally and independently substituted by at least one substituent selected from the group consisting of ═O and Y1, and said A9 is C1-6 alkyl, each of said B8 and B9 is optionally substituted by one or more substituents independently selected from Y2, said B8 is aryl and said B9 is heteroaryl;
• each Y1 independently is halo, —O—R30, —CN, B10 or B11 wherein each of said B10 and B11 is optionally substituted by at least one substituent selected from the group consisting of halo, —O—C1-3alkyl and C1-3 alkyl and said B10 is aryl, and said B11 is heteroaryl;
• each Y2 independently is halo, A10 or A11;
• wherein each of said A10 and A11 is optionally substituted by at least one fluoro, said A10 is —OC1-6alkyl, and said A11 is C1-6 alkyl;
• each R30 independently is hydrogen, A12, B12 or B13, wherein said A12 is optionally substituted by at least one fluoro, said A12 is C1-6 alkyl, each of said B12 and B13 is independently and optionally substituted by at least one substitutent selected from the group consisting of halo, —O—C1-3alkyl and C1-3 alkyl, said B12 is aryl, and said B13 is heteroaryl;
• or a pharmaceutically acceptable salt thereof.