Imidazol-piperidinyl derivatives as modulators of kinase activity

A compound of formula (I),

• or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof,
• wherein:
• X1 is N or CH,
• X2 is CH2 or NH,
• X3 is CH2 or CO,
• X4 is O, CH2 or NH,
• R1 is Ar, Het, or unbranched or branched alkyl with 1-10 C-atoms, each of which is substituted by 1-6 of Hal, A, phenyl, CON(R3)2, COOR3, NHCOA, NHSO2A, CHO, COA, SO2N(R3)2, SO2A, [C(R3)2]pOR3, [C(R3)2]pN(R3)2 and/or [C(R3)2]pCN;
• R2 is [C(R3)2]pHet1 or A,
• each R3 is independently H or alkyl with 1, 2, 3, or 4 C-atoms,
• Ar is phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, phenyl, CON(R3)2, COOR3, NHCOA, NHSO2A, CHO, COA, SO2N(R3)2, SO2A, [C(R3)2]pOR3, [C(R3)2]pN(R3)2 and/or [C(R3)2]pCN,
• Het is furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzimidazolyl, indazolyl or quinolyl, which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R3)2]pOR3, [C(R3)2]pN(R3)2, NO2, CN, [C(R3)2]pCOOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA and/or O[C(R3)2]qN(R3)2,
• Het1 is dihydropyrrolyl, pyrrolidinyl, azetidinyl, oxetanyl, tetrahydroimidazolyl, dihydropyrazolyl, tetrahydropyrazolyl, tetrahydrofuranyl, dihydropyridyl, tetrahydropyridyl, piperidinyl, azepanyl, morpholinyl, hexahydropyridazinyl, hexahydropyrimidinyl, [1,3]dioxolanyl, tetrahydropyranyl, pyridyl or piperazinyl, which is unsubstituted or mono- or disubstituted by A,
• each A is independently unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH- and/or CH2-groups may be replaced by N-, O- and/or S-atoms and wherein 1-7 H-atoms may be replaced by F or Cl,
• each Hal is independently F, Cl, Br or I,
• each m is independently 0, 1 or 2,
• each n is independently 0, 1 or 2,
• each p is independently 0, 1, 2, 3 or 4,
• each q is independently 2, 3 or 4,
• with the proviso, that compounds are excluded wherein
• X2=NH, X3=CO and n=0.