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US 9,315,512 B2Granted
Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
AssigneeShionogi & Co., Ltd.
InventorsYoshinori Tamura, Kouichi Noguchi, Masanao Inagaki, Nobuhiro Haga
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Abstract
Stable crystalline forms of a compound represented by the formula (IA): an acid addition salt, and/or a solvate thereof are provided by the present invention. Said crystalline forms are extremely useful as materials for preparing medicines. Novel processes for preparing 6,7-unsaturated-7-carbamoyl morphinan derivatives are also provided by the present invention.
Claims5
A process for preparing a crystal of an acid addition salt of a compound of the formula (IA):
- comprising:
- adding an acid to the compound of the formula (IA), and
- optionally crystallizing the acid addition salt from a solvent.
A process for preparing a crystal of a p-toluenesulfonic acid salt of a compound of the formula (IA)
- comprising:
- treating with a base a compound of the formula (IID):
- wherein R1 is hydrogen or a hydroxyl-protecting group,
- 2) adding p-toluenesulfonic acid after deprotecting R1, and
- 3) optionally crystallizing the acid addition salt from a solvent.
2 more elements
Dependencies are inferred from the claim text.