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US 9,315,500 B2Granted
Bicyclic heteroaryl cycloalkyldiamine derivatives
AssigneeNovartis AG
InventorsPeter Buehlmayer, Alexander Baxter Smith, Gebhard Thoma, Maurice Van Eis
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Abstract
The present invention relates to bicyclic heteroaryl cycloalkyldiamine derivatives, to processes for their production, to their use as SYK inhibitors and to pharmaceutical compositions comprising them. Formula (I)
Claims9
A compound of the formula (I) or a pharmaceutically acceptable salt thereof,
- wherein
- X1 is CR1;
- X2 is CH;
- Y is CH2 or O;
- A is bicyclic hetereoaryl having from 8 to 10 ring atoms, wherein 1-3 of said ring atoms are heteroatoms selected from N, O and S and wherein said heteroaryl may be unsubstituted of substituted at a carbon atom by a R2 or at a nitrogen atom by a R3;
- R1 is H, Hal or C1-4 alkyl;
- R2 is H, C1-4 alkyl, C3-5 cycloalkyl, CN or Hal;
- and
- R3 is H or alkyl.
6 more elements
Dependencies are inferred from the claim text.