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US 9,315,499 B2Granted
Cytomegalovirus inhibitor compounds
AssigneeBoehringer Ingelheim International GmbH
InventorsLee Fader, Olivier Lepage, Murray Bailey, Pierre Louis Beaulieu, Francois Bilodeau, Rebekah J. Carson, André Giroux, Cédrickx Godbout, Benoît Moreau, Julie Naud, Mathieu Parisien, Martin Poirier, Maude Poirier, Simon Surprenant, Carl Thibeault
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Abstract
Compounds of Formula (I) wherein n, m, R1, R2, R3, R4, R5 and R6 are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.
Claims21
A compound of Formula (I):
- wherein
- m is 1, 2 or 3;
- n is 1, 2 or 3;
- R1 is halo, —CN, (C1-6)alkyl, OH, —O—(C1-6)alkyl, (C1-6)haloalkyl or nitro;
- R2 is H or (C1-6)alkyl optionally substituted with halo, —CN, (C1-6)alkyl, (C1-6)haloalkyl, —(C3-7)cycloalkyl , —O—(C1-6)alkyl, OH ,—NH2, —NH(C1-6)alkyl or —N((C1-6)alkyl)2;
- R3 is H, (C1-6)alkyl, (C3-7)cycloalkyl, aryl, heterocyclyl, heteroaryl, —(C1-6)alkyl-(C3-7)cycloalkyl, —(C1-6)alkyl-aryl, —(C1-6)alkyl-heterocyclyl or —(C1-6)alkyl-heteroaryl, wherein each said alkyl, cycloalkyl, aryl, heterocyclyl and heteroaryl, either alone or in combination with another radical, is optionally mono-, di-, or tri-substituted with R32;
- or R2 and R3, together with the N to which they are attached, are linked to form a heterocyclyl or heteroaryl;
- wherein each said heterocyclyl and heteroaryl are optionally mono-, di-, or tri-substituted with R32;
- R32 is each independently selected from the group consisting of R33, halo, oxo, —CN, OH, SH, —COOH, —O—(C1-6)alkyl, —S—(C1-6)alkyl, (C3-7)cycloalkyl, (C1-6)haloalkyl, —C(═O)—(C1-6)alkyl, —C(═O)—O—(C1-6)alkyl, —SO2NH2, —SO2—NH(C1-6)alkyl, —SO2—N((C1-6)alkyl)2, —SO(C1-6)alkyl, —SO2(C1-6)alkyl, —C(═O)—NH2, —C(═O)—NH(C1-6)alkyl, —C(═O)—N((C1-6)alkyl)2, —C(═O)—NH—SO2(C1-6)alkyl, —SO2—NH—C(═O)—(C1-6)alkyl, —NH2, —NH(C1-6)alkyl, —N((C1-6)alkyl)2, —NH(C3-7)cycloalkyl, —N((C1-6)alkyl)(C3-7)cycloalkyl, —NH—C(═O)(C1-6)alkyl, —NH—C(═O)—O(C1-6)alkyl, heterocyclyl (optionally substituted with (C1-6)alkyl) and heteroaryl (optionally substituted with (C1-6)alkyl);
- R33 is (C1-6)alkyl optionally mono-or di-substituted with OH, —O—(C1-6)alkyl, —NH2, —NH(C1-6)alkyl or —N((C1-6)alkyl)2;
- R4, R5 and R6 are each independently selected from the group consisting of halo, —CN, nitro, R42, —C(═O)—R42, —C(═O)OR42, —OR42, —SR42, —SOR42, —SO2R42, —N(R43)R42, —(C1-6)alkyl—N(R43)R42, —C(═O)—N(R43)R42, —N(R43)—C(═O)R42, —N(R43)—C(═O)—OR42, —O—C(═O)—N(R43)R42, —C(═O)—N(H)—SO2R42, —SO2—N(H)—C(═O)R42, —N(R43)—SO2R42 and —SO2—N(R43)R42;
- R42 is each independently selected from the group consisting of H, (C1-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, —(C1-6)alkyl-(C3-7)cycloalkyl, —(C1-6)alkyl-aryl, —(C1-6)alkyl-heterocyclyl, —(C1-6)alkyl-heteroaryl, (C3-7)cycloalkyl, aryl, heterocyclyl and heteroaryl, wherein each said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl and heteroaryl, either alone or in combination with another radical, is optionally substituted with 1 to 3 substituents each independently selected from the group consisting of:
- oxo, halo, —CN, OH, —COOH, —O—(C1-6)alkyl, —S—(C1-6)alkyl, (C3-7)cycloalkyl, —O—(C3-7)cycloalkyl, (C1-6)haloalkyl, —C(═O)—O—(C1-6)alkyl, —SO2NH2, —SO2—NH(C1-6)alkyl, —SO2—N((C1-6)alkyl)2, —SO(C1-6)alkyl, —SO2(C1-6)alkyl, —C(═O)—NH2, —C(═O)—NH(C1-6)alkyl, —C(═O)—N((C1-6)alkyl)2, —NH2, —NH(C1-6)alkyl, —N((C1-6)alkyl)2, —NH—C(═O)(C1-6)alkyl, —NH—C(═O)—O—(C1-6)alkyl, —C(═O)—N(H)—SO2(C1-6)alkyl, —SO2—N(H)—C(═O)(C1-6)alkyl, and (C1-6)alkyl optionally mono-or di-substituted with OH, —O—(C1-6)alkyl, —S—(C1-6)alkyl, —SO(C1-6)alkyl, —SO2(C1-6)alkyl, —NH2, —NH(C1-6)alkyl, —N((C1-6)alkyl)2, —C(═O)-heterocyclyl, —C(═O)-heteroaryl, aryl, heterocyclyl or heteroaryl;
- R43 is H, (C1-6)haloalkyl or (C1-6)alkyl optionally mono-or di-substituted with OH, —O—(C1-6)alkyl, or —O—(C3-7)cycloalkyl;
- or a salt thereof.
12 more elements
Dependencies are inferred from the claim text.