Benzopyrone derivative and use thereof
AssigneesHuazhong University of Science and Technology, Nhwa Pharma. Corporation
InventorsGuisen Zhang, Yin Chen, Xiangqing Xu, Bifeng Liu, Xin Liu, Song Zhao, Shicheng Liu, Minquan Yu, Heng Zhang, Xinghua Liu
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Abstract
The present invention relates to the field of pharmaceutical chemistry, and in particular, to a benzopyrone derivative and a use thereof. The benzopyrone derivative is compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof. It has been found by experiments that, this type of compounds is useful in prevention or treatment of neuropsychical diseases.
Claims13
A benzopyrone derivative having the structure of formula (I) or a pharmaceutically acceptable salt thereof,
- wherein,
- Z is —O(CH2)n, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of hydroxyl and C1-5alkyl, wherein n is an integer of 2-6, and the carbon chain of Z optionally has a double bond(s);
- Y is O or S;
- Q is N or CH;
- X is O, S or NH;
- the dashed line represents a single bond or a double bond;
- R1, R3, R4 and R5 are each independently H;
- halogen;
- cyano;
- hydroxyl;
- aryl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of halogen, amino and hydroxyl;
- C1-5alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of halogen, amino and hydroxyl;
- or C1-5alkoxy, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of halogen, amino and hydroxyl;
- R2 is H;
- or C1-5alkyl, which is unsubstituted or substituted by one or more substituents independently selected from the group consisting of halogen, amino and hydroxyl.
Dependencies are inferred from the claim text.