Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses

A compound having the following formula (I):

• or a stereoisomer or pharmaceutically-acceptable salt thereof, wherein:
• R1 is C1-3alkyl optionally substituted by 0-7 R1a;
• R1a at each occurrence is independently hydrogen, deuterium, F, Cl, Br, CF3 or CN;
• R2 is pyridyl substituted with 0-3 R2a;
• R2a at each occurrence is independently hydrogen, ═O, halo, OCF3, CN, NO2, —(CH2)rORb, —(CH2)rSRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, —S(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, —(CH2)r-3-14 membered carbocycle substituted with 0-1 Ra, —(CH2)r-5-7 membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-2 Ra;
• and —(CH2)r-5-7 membered heterocycle comprising carbon atoms or 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-2 Ra;
• R3 is phenyl, pyridyl, cyclopentyl, cyclohexyl, furanyl, pyridyl or pyranyl, each substituted with 0-3 R3a;
• R3a at each occurrence is independently hydrogen, ═O, halo, OCF3, OCHF2, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rSRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, —S(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, a —(CH2)r-5-7 membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, S or O substituted with 0-3 Ra, or a —(CH2)r-5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra;
• or two R3a, together with the atoms to which they are attached, combine to form a fused ring wherein said ring is selected from phenyl and a 5-7 membered heterocycle or heteroaryl, each comprising carbon atoms and 1-4 heteroatoms selected from N, S or O;
• R4 and R5 are independently hydrogen, C1-4 alkyl substituted with 0-1 Rf, (CH2)r-phenyl substituted with 0-3 Rd, or a —(CH2)-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p;
• R11 at each occurrence is independently hydrogen, C1-6 alkyl substituted with 0-3 Rf, CF3, C3-10 cycloalkyl substituted with 0-3 Rf, (CH)r-phenyl substituted with 0-3 Rd, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rd;
• Ra at each occurrence is independently hydrogen, ═O, F, Cl, Br, OCF3, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rSRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, —S(O)Rc, —S(O)2Rc, C1-6 alkyl substituted with 0-3 Rf, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, —(CH2)r-3-14 membered carbocycle, —(CH2)r-5-7 membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf;
• or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf, alternatively two Ra on adjacent or the same carbon atom form a cyclic acetal of the formula —O—(CH2)n—O—, or —O—CF2—O—, wherein n is selected from 1 or 2;
• Rb is hydrogen, C1-6 alkyl substituted with 0-3 Rd, C1-6 haloalkyl, C3-6 cycloalkyl substituted with 0-2 Rd, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf, or (CH2)r-phenyl substituted with 0-3 Rd;
• Rc is C1-6 alkyl substituted with 0-3 Rf, (CH2)r—C3-6 cycloalkyl substituted with 0-3 Rf, (CH2)r-phenyl substituted with 0-3 Rf;
• or
• Rd at each occurrence is independently hydrogen, F, Cl, Br, OCF3, CF3, CN, NO2, —ORe, —(CH2)rC(O)Rc, —NReRe, —NReC(O)ORc, C1-6 alkyl, or (CH2)r-phenyl substituted with 0-3 Rf;
• Re is selected from hydrogen, C1-6 alkyl, C3-6 cycloalkyl, and (CH2)r-phenyl substituted with 0-3 Rf;
• Rf independently at each occurrence is hydrogen, halo, CN, NH2, NH(C1-6alkyl), N(C1-6alkyl)2, OH, C3-6 cycloalkyl, CF3, O(C1-6alkyl), phenyl;
• or Rf independently at each occurrence is an optionally substituted —(CH2)r-5-10 membered heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) or C3-6 cycloalkyl, each group optionally substituted with halo, CN, CF3, C1-6 alkyl or O(C1-6alkyl);
• p is 0, 1, or 2;
• and
• r is 0, 1, 2, 3, or 4;
• provided that the compound of formula (I) is not