Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDaria Mochly-Rosen, Che-Hong Chen, Xiaohu Ouyang
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Abstract
The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
Claims10
A method of treating an ischemic stress condition in an individual in need thereof, the method comprising administering to the individual an effective amount of a pharmaceutical composition comprising:
- (a) a compound selected from the group consisting of:
- and
- (b) a pharmaceutically acceptable excipient,
- wherein said administering is effective to treat an ischemic stress condition selected from the group consisting of limb ischemia, myocardial infarct and stroke in the individual.
A method of treating an ischemic stress condition in an individual in need thereof, the method comprising administering to the individual an effective amount of a pharmaceutical composition comprising:
- (a) a compound of the formula:
- and
- (b) a pharmaceutically acceptable excipient,
- wherein said administering is effective to treat an ischemic stress condition selected from the group consisting of limb ischemia, myocardial infarct and stroke in the individual.
Dependencies are inferred from the claim text.