US 9,315,472 B2 · 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof

Abstract

The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.

Claims25

Dependent claims

A compound of Formula (I):

or a salt thereof;
wherein:
each instance of RA is independently substituted or unsubstituted C6-13 alkyl;
each instance of RB is independently substituted or unsubstituted C6-13 alkyl;
and
each instance of m is independently 1, 2, 3, 4, 5, or 6.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/267,530Filed 1 May 2014 · us provisional application

Priority

1 May 2013

Published

US 2014/0329884 A16 Nov 2014

Granted

19 Apr 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07D 251/30
With only hetero atoms directly attached to ring carbon atoms: only oxygen atoms
A61K 31/53
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with three nitrogens as the only ring hetero…
A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides
C07D
Heterocyclic compounds

1,3,5-triazinane-2,4,6-trione derivatives and uses thereof

Life of this patent

1,3,5-triazinane-2,4,6-trione derivatives and uses thereof

Life of this patent

Abstract

Claims25