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US 9,315,471 B2Granted
Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
AssigneeGenetech, Inc.
InventorsSrinivasan Babu, Francis Gosselin, Yingqing Ran, Travis Remarchuk, Scott J. Savage, Jeffrey Stults, Herbert Yajima
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Abstract
The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt of (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
Claims16
A process comprising contacting a compound of formula II or a salt thereof:
- wherein:
- R1 is hydrogen or an amino protecting group;
- with a ketoreductase enzyme or an alcohol dehydrogenase enzyme to form a compound of formula III:
- or a salt thereof.
1 more element
Dependencies are inferred from the claim text.