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US 9,315,469 B2Granted
Process for drying bendamustine hydrochloride monohydrate
AssigneeJohnson Matthey Public Limited Company
InventorsXing Fu, Jeremy Clinton Wilt
Life of this patent
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Abstract
Wet bendamustine hydrochloride monohydrate may be dried by a two stage process wherein rapid drying is first carried out to provide a partially dried product, which is then further dried using an inert gas of controlled relative humidity to yield dry bendamustine hydrochloride monohydrate.
Claims18
A method of obtaining dry bendamustine hydrochloride monohydrate, comprising the steps of:
- a) drying wet bendamustine hydrochloride monohydrate under conditions effective to yield partially dried bendamustine hydrochloride monohydrate having a moisture content of about 4.4% to about 19%;
- and
- b) contacting the partially dried bendamustine hydrochloride monohydrate with an inert gas of controlled relative humidity to yield dry bendamustine hydrochloride monohydrate.
Dependencies are inferred from the claim text.