Substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors

The method of preparing a compound of Formula 1c, or a salt thereof,

• the method comprising the step of coupling a compound of Formula 1a
• with a compound Formula 1b
• wherein:
• m is selected from the group consisting of 0 and 1;
• R1 is independently selected from the group consisting of chloro, fluoro, bromo, cyano, and methoxy;
• R2b and R2c are independently selected from the group consisting of hydrogen, chloro, fluoro, methyl, trifluoromethyl, cyano, methoxy, and N(CH3)2;
• RA and RB are independently selected from the group consisting of H and Me;
• RC and RD are independently or together a group that can by hydrolyzed to hydroxyl;
• n is selected from the group consisting of 0 and 1;
• and
• R3 is independently selected from the group consisting of fluoro, chloro, bromo, methyl, trifluoromethyl, cyano, methoxy, and N(CH3)2.