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US 9,315,457 B2Granted
Crystalline polymorphic forms of an antidiabetic compound
AssigneeMerck Sharp & Dohme Corp.
InventorJohn Y. L. Chung
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Abstract
The present invention relates to polymorphic forms of a compound of formula A: This compound is useful as a glucagon receptor antagonist and serves as a pharmaceutically active ingredient for the treatment of type 2 diabetes and related conditions, such as hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. Hydrates, hemihydrates, anhydrates and similar polymorphic forms are included.
Claims4
A process for synthesizing a compound of formula A:
- comprising deprotecting a compound of formula 11a:
- wherein P1 and P2 represent protecting groups, to produce a compound of formula A.
A process for synthesizing a compound of formula A:
- comprising reacting a compound of formula 10a:
- wherein P1 represents a protecting group with a beta alanine ester of the formula
- H2NCH2CH2CO2P2
- wherein P2 represents a protecting group, with a peptide coupling agent, to produce a compound of formula 11a:
- and deprotecting compound 11a to produce a compound of formula A.
2 more elements
A process for the synthesis of a compound of formula A:
- comprising reacting a compound of the formula 11:
- with base to produce a compound of formula A.
Dependencies are inferred from the claim text.