Process for preparing benzofuran-2-carboxamide derivatives
AssigneeSymed Labs Limited
InventorsMohan Rao Dodda, Jithender Aadepu
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Abstract
Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity. Provided also herein is an improved and commercially viable process for the preparation of 3-(4-hydroxybutyl)-1H-indole-5-carbonitrile, in high yield and purity, using novel intermediate compound 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile.
Claims4
A compound, 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile, of formula VIII:
- or a salt thereof.
A process for the preparation of 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile of formula VIII:
- or a salt thereof, comprising:
- a) reacting 5-cyanoindole of formula IX:
- with 4-chlorobutyryl chloride of formula X:
- in the presence of a Lewis acid in a suitable solvent to produce a reaction mass;
- b) isolating the compound from the reaction mass obtained in step-(a);
- and
- c) reacting the compound obtained in step-(b) with an alcohol or an aqueous alcohol to produce 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile of formula VIII or a salt thereof.
Dependencies are inferred from the claim text.