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US 9,315,454 B2Granted
Compounds which modulate the CB2 receptor
AssigneeBoehringer Ingelheim International GmbH
InventorsAlessandra Bartolozzi, Angela Berry, Doris Riether, Monika Ermann, James Edward Jenkins, Innocent Mushi
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
Claims12
A compound of the formula (I)
- wherein:
- R1 is phenyl wherein each R1 is optionally substituted with 1-3 substituents chosen from C1-4 alkyl group substituted with 1-3 halogens, or from C3-10 cycloalkyl , C1-4 alkoxy, C1-4 alkylsulfonyl, acyl, cyano, hydroxyl and halogen;
- R2 and R3 are C1-4 alkyl or hydrogen with the proviso that both R2 and R3 cannot be hydrogen;
- R4 is hydrogen or methyl;
- R5 is phenyl wherein each R5 is optionally substituted with 1-3 substituents chosen from C1-4 alkyl group optionally substituted with 1-3 halogens, C1-4 alkoxy, acyl, —C(O)-heteroaryl, cyano, hydroxyl and halogen;
- R6 is hydrogen or C1-4 alkyl;
- n is 1, 2, 3 or 4;
- wherein any carbon atom on the formula (I) or any R substituent listed above is optionally partially or fully halogenated where possible;
- or a pharmaceutically acceptable salt thereof.
6 more elements
A compound of the formula (IA)
- wherein
- of the formula (IA) is chosen from any of A1-A16 in Table I, and
- of the formula (IA) is chosen from any of B1 -B15 in Table I,
- TABLE I
- A1
- A2
- A3
- A4
- A5
- A6
- A7
- A8
- A9
- A10
- A11
- A12
- A13
- A14
- A15
- A16
- B1
- B2
- B3
- B4
- B5
- B6
- B7
- B8
- B9
- B10
- B11
- B12
- B13
- B14
- B15
- or a pharmaceutically acceptable salt thereof.
33 more elements
A compound chosen from
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.