4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene crystal
AssigneeKyorin Pharmaceutical Co., Ltd.
InventorsTakeshi Tsubuki, Hiroya Sato
Life of this patent
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Abstract
[Problem] For example, 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene (compound 1) is used as an intermediate for producing a 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride which has excellent immunosuppressive activity. This compound 1 is traditionally obtained only as an oil and thus handling and refining were difficult. [Solution] A crystal of the compound 1 is obtained. A method of crystallizing the same is also established. Furthermore, a simple refining method is also found which comprises stirring in suspension the crystal in a solvent. Since the compound 1 can be obtained as a crystal, it is easier to handle and long term storage is possible.
Claims8
A crystal of 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene, wherein, in powder X-ray diffraction using CuKα radiation with 2θ representing a diffraction angle, a powder X-ray diffraction image including the following 2θ peaks is observed:
- 2θ:
- 9.7, 12.9, 16.4, 16.8, 17.6, 19.5, 21.7, 22.6, 22.9, 23.3, 24.5, 24.8, 26.0, 26.4, 27.2.
A crystal of 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene, wherein a powder X-ray diffraction image the same as an image in FIG. 1 is obtained by powder X-ray diffraction using CuKα radiation with 2θ representing a diffraction angle.
Dependencies are inferred from the claim text.