US 9,315,449 B2Granted

Substituted pyrazoles as heat shock transcription factor activators

AssigneesDuke University, Chaperone Therapeutics, Inc.

InventorsDennis J Thiele, Daniel W Neef, Jose S Mendoza

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Abstract

The present invention relates to substituted pyrazole compounds, methods for their discovery, and their research and therapeutic uses, and pharmaceutical Formulations thereof. In particular, the present invention provides substituted pyrazole compounds capable of facilitating HSF1 homotrimerization, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with irregular HSF1 activity.

Claims1

Dependent claims

A compound selected from the group consisting of:

Dependencies are inferred from the claim text.

Facts

Application: 12/945,522Filed 12 Nov 2010 · continuation in part
Priority: 15 May 2008
Published: US 2011/0112073 A112 May 2011
Granted: 19 Apr 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification30 codes

C07C 211/01
Compounds containing amino groups bound to a carbon skeleton: having amino groups bound to acyclic carbon atoms
A61K 31/415
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2-Diazoles
A61K 31/4155
1,2-Diazoles: non condensed and containing further heterocyclic rings
A61K 31/426
Thiazoles: 1,3-Thiazoles

Family

Application61/053,513Us provisional application · filed 15 May 2008
PCT/US2009/044186Parent of this continuation-in-part · filed 15 May 2009
US 2011/0112073 A1Pre-grant publication · published 12 May 2011
US 9,315,449 B2This patent

From the US filing history. Foreign family members aren’t listed.

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