Device for the chromatographic separation of a substance mixture and use thereof
AssigneeFresenius Medical Care Deutschland GmbH
InventorsHans-Peter Leinenbach, Franz-Josef Gerner, Stefan Kuhn, Patrick Priesnitz
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Abstract
A multifunctional device for chromatographic separation, in particular for affinity chromatographic separation of a substance mixture, provides for a uniform fluid distribution on a separation medium and a uniform flow through a stationary phase. The fluid to be separated is passed through a radial inlet line in an upper partial region of the device, to the center of the upper partial region. The radial inlet line is enlarged in the form of a cupola at the center of the upper partial region.
Claims59
A device for chromatographic separation of a substance mixture, comprising:
- a housing;
- a central partial region containing a separation medium;
- an upper partial region having an inlet channel that extends radially from an outer circumferential edge of the upper partial region to a center point in a middle of an upper plane of the upper partial region;
- a lower partial region having an outlet channel;
- and
- separation elements, which separate the upper partial region and the lower partial region from the separation medium,
- the inlet channel (i) enlarging in a cupola-shaped enlargement at the center point of the upper plane of the upper partial region and (ii) being open in a direction toward the central partial region from an outer circumferential edge of the upper partial region to the cupola-shaped enlargement.
A device for chromatographic separation of a substance mixture, said device comprising:
- a housing;
- a central partial region containing a separation medium;
- a first partial region having a first channel that extends radially from an outer circumferential edge of the first partial region to a center point in a middle of an upper plane of the first partial region;
- a second partial region having a second channel that extends radially from an outer circumferential edge of the second partial region to a center point in a middle of a lower plane of the second partial region;
- and
- separation elements, which separate the first partial region and the second partial region from the separation medium,
- the first channel terminating in a first cupola-shaped enlargement at the center point of the upper plane of the first partial region, and the second channel terminating in a second cupola-shaped enlargement at the center point of the lower plane of the second partial region,
- with the first channel being open in a direction toward the central partial region from an outer circumferential edge of the first partial region to the first cupola-shaped enlargement, and the second channel being open in a direction toward the central partial region from an outer circumferential edge of the second partial region to the second cupola-shaped enlargement.
Dependencies are inferred from the claim text.