Drug releasing coatings for balloon catheters
AssigneeLutonix, Inc.
InventorLixiao Wang
Life of this patent
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Abstract
Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
Claims20
A balloon catheter for delivering a therapeutic agent to a blood vessel while the balloon catheter is deployed at a target site of the blood vessel, the balloon catheter comprising:
- an elongate member having a lumen and a distal end,
- an expandable balloon attached to the distal end of the elongate member and in fluidic communication with the lumen;
- and
- a coating layer overlying an exterior surface of the expandable balloon,
- wherein:
- the coating layer comprises a total drug load of a hydrophobic therapeutic agent and a combination of additives comprising a first additive and a second additive;
- the hydrophobic therapeutic agent is one of paclitaxel or analogs thereof, rapamycin or analogs thereof, daunorubicin, doxorubicin, beta-lapachone, biologically active vitamin D, or combinations thereof;
- the first additive is one of PEG sorbitan monolaurates, PEG sorbitan monooleates, or combinations thereof;
- and
- the second additive is one of sorbitol, sorbitan, xylitol, gluconolactone, lactobionic acid, or combinations thereof.
A balloon catheter for delivering a therapeutic agent to a blood vessel while the balloon catheter is deployed at a target site of the blood vessel, the balloon catheter comprising:
- an elongate member having a lumen and a distal end,
- an expandable balloon attached to the distal end of the elongate member and in fluid communication with the lumen;
- and
- a coating layer overlying an exterior surface of the expandable balloon,
- wherein:
- the coating layer comprises a total drug load of a hydrophobic therapeutic agent and a combination of additives comprising a first additive and a second additive;
- the total drug load of the hydrophobic therapeutic agent is from 2.5 μg to 6 μg per square millimeter of the expandable balloon;
- the hydrophobic therapeutic agent is one of paclitaxel or analogs thereof, rapamycin or analogs thereof, daunorubicin, doxorubicin, beta-lapachone, biologically active vitamin D, or combinations thereof;
- the first additive is one of PEG-20 sorbitan monolaurate, PEG-20 sorbitan monooleate, or combinations thereof;
- the second additive is one of sorbitol, gluconolactone, or combinations thereof;
- and
- the ratio by weight of the combination of additives in the coating layer to the hydrophobic therapeutic agent in the coating layer is about 10 to 0.5.
Dependencies are inferred from the claim text.