Back to results
US 9,314,551 B2Granted
Block copolymer-coated endoprosthesis
AssigneeBoston Scientific Scimed, Inc.
InventorsLiliana Atanasoska, Mourad Rahi, Robert W. Warner
Life of this patent
Estimating the term…
Abstract
In embodiments, a stent includes a copolymer having a modulus of about 10 MPa or less and exhibiting hydrolytic degradation substantially by surface erosion. For example, the copolymer can include elastic segments formed of trimethyl carbonate polymer or copolymer, and rigid segments formed of a lactide, glycolide, ε-caprolactone polymer or copolymer.
Claims11
A stent, comprising:
- a biodegradable metal stent body comprising Mg, Fe, or an alloy thereof;
- a copolymer coating disposed directly on the biodegradable metal stent body, the copolymer coating comprising elastic segments and rigid segments, the elastic segments being formed of a trimethyl carbonate polymer or copolymer that degrades by bulk hydrolysis, the rigid segments comprising a lactide, glycolide, ε-caprolactone polymer or copolymer that degrades by enzymatic surface erosion, the copolymer coating being cross-linked, the copolymer coating having an elastic modulus of 10 MPa or less and exhibiting degradation by surface erosion over a period of 20 days or more;
- and
- one or more inorganic materials mixed into the copolymer coating;
- wherein the copolymer coating is functionalized with maleic anhydride.
2 more elements
A stent, comprising:
- a biodegradable metal stent body comprising Mg, Fe, or an alloy thereof;
- a copolymer coating disposed directly on the biodegradable metal stent body, the copolymer coating comprising elastic segments and rigid segments;
- wherein the elastic segments are formed of a trimethyl carbonate polymer or copolymer that degrades by bulk hydrolysis;
- wherein the rigid segments comprise a lactide, glycolide, ε-caprolactone polymer or copolymer that degrades by enzymatic surface erosion;
- wherein the copolymer coating is cross-linked by irradiation;
- wherein the copolymer coating has an elastic modulus of 20 MPa or less and exhibits degradation over a period of 20 days or more;
- and
- a therapeutic agent incorporated into the copolymer coating;
- wherein the elastic segments are functionalized with maleic anhydride for abluminal surface adhesion.
6 more elements
A stent, comprising:
- a biodegradable metal stent body comprising iron;
- a copolymer coating disposed directly on the biodegradable metal stent body, the copolymer coating comprising elastic segments and rigid segments;
- wherein the elastic segments are formed of a trimethyl carbonate polymer or copolymer that degrades by bulk hydrolysis;
- wherein the rigid segments comprise a lactide, glycolide, ε-caprolactone polymer or copolymer that degrades by enzymatic surface erosion;
- wherein the copolymer coating is cross-linked by irradiation;
- wherein the copolymer coating has an elastic modulus of 20 MPa or less and exhibits degradation over a period of 20 days or more;
- and
- a therapeutic agent incorporated into the copolymer coating;
- wherein the elastic segments are functionalized with maleic anhydride for abluminal surface adhesion.
6 more elements
Dependencies are inferred from the claim text.