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US 9,314,549 B2Granted
Bone tissue biomimetic materials
AssigneeUniversity of South Carolina
InventorEsmaiel Jabbari
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AssigneeUniversity of South Carolina
InventorEsmaiel Jabbari
Estimating the term…
Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues. The materials can incorporate high levels of mineralization so as to provide mechanical strength and promote osteogenesis and/or osteoconductivity on/in the bone tissue biomimetic materials. The materials and constructs can be utilized in forming tissue engineered structures for in vitro and in vivo use. Macroscopic bone tissue biomimetic scaffolds formed from the materials can be seeded with osteogenic cells and utilized to develop bone graft materials that can exhibit strength and osteoconductivity similar to the native bone and that exhibit uniform distribution of nutrients in the scaffolds.
A bone tissue biomimetic material comprising a fibrous sheet, the fibrous sheet including polymeric nanofibers, the polymeric nanofibers being formed from a composition that includes a biocompatible polymer conjugated to a peptide such that the polymeric nanofibers include the biocompatible polymer conjugated to the peptide at a surface, the peptide comprising multiple acidic amino acid residues, the polymeric nanofibers comprising the acidic amino acid residues at a surface of each nanofiber in an amount of from about 1 to about 10 nanomoles per square centimeter.
Dependencies are inferred from the claim text.