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US 9,314,540 B2Granted
Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system
AssigneePiramal Imaging SA
InventorsAndrea Thiele, Georg Kettschau, Tobias Heinrich, Lutz Lehmann, Christer Halldin, Sangram Nag, Andrea Varrone, Balazs Gulyas
Life of this patent
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Abstract
This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors.
Claims19
A compound of formula I:
- wherein
- D is deuterium;
- R1 is selected from methyl, ethyl, n-propyl, n-butyl, and iso-butyl;
- R2 is [18F]fluorine;
- and
- n and m are each selected from 0 and 1;
- with the provisos that:
- if n=0, m must be 1, and
- if n=1, m must be 0;
- including all stereoisomeric forms of said compound, including but not limited to enantiomers and diastereoisomers as well as racemic mixtures,
- including salts thereof with an organic or inorganic acids.
8 more elements
Dependencies are inferred from the claim text.