Conformations of divergent peptides with mineral binding affinity
AssigneeKaohsiung Medical University
InventorsHui-Ting Chen, Kuang-Chan Hsieh, Je-Ken Chang, Gwo-Jaw Wang, Yin-Chih Fu, Mei-Ling Ho, Cherng-Chyi Tzeng
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Abstract
A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
Claims2
A pharmaceutical composition with mineral affinity, comprising a pharmaceutically acceptable carrier, and an effective amount of a compound having a formula 2:
- wherein G is a polyamindoamine dendrimer (PAMAM);
- the sum of A and B is (4×2Y), where A, B and Y are natural numbers larger than 0 and Y is a number of generation;
- Asp represents an aspartic acid;
- and a ratio of the Asp modified on G is determined by the equation of (the number of B)/(the sum of A and B)×100% and is ranged between 21% and 46%.
A divergent compound with mineral affinity, comprising a structure having a formula 2:
- wherein G is a polyamindoamine dendrimer (PAMAM);
- the sum of A and B is (4×2Y), where A, B and Y are natural numbers larger than 0 and Y is a number of generation;
- and Asp represents an aspartic acid;
- and a ratio of the Asp modified on G is determined by the equation of (the number of B)/(the sum of A and B)×100% and is ranged between 21% and 46%.
Dependencies are inferred from the claim text.