Drug delivery vehicle
AssigneesUniversity of North Texas Health Science Center, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAndras G. Lacko, Alan T. Remaley, Nirupama A. Sabnis
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Abstract
The present disclosure provides targeted drug delivery vehicle compositions comprising a drug composition and targeted poly-amino-acid subunits, methods of manufacture, and methods of treatment for numerous diseases.
Claims31
A targeted drug delivery vehicle composition consisting essentially of:
- a drug composition and 5-50 targeted poly-amino-acid subunits,
- wherein each of the targeted poly-amino-acid subunits comprise a targeting amino acid chain conjugated to a fatty acid, and
- wherein the targeting amino acid chain comprises at least 70% identity to SEQ ID NOs:
- 20, 63, 64, 65, or 66;
- and has affinity to a scavenger receptor class B 1 or portion thereof.
A targeted drug delivery vehicle consisting essentially of:
- a drug composition and 5-50 targeted poly amino-acid subunits,
- wherein each of the targeted poly-amino-acid subunits comprise a polynucleotide drug composition, a phospholipid, an excipient, and a targeting amino acid chain, and
- wherein the targeting amino acid chain comprises at least 70% identity to SEQ ID NOs:
- 20, 63, 64, 65, or 66, and has affinity to a scavenger receptor class B 1 or a portion thereof.
A targeted drug delivery vehicle composition consisting essentially of:
- a drug composition and 5-50 targeted poly-amino-acid subunits,
- wherein each of the targeted poly-amino-acid subunits comprise a targeting amino acid chain conjugated to a fatty acid, and
- wherein the targeting amino acid chain:
- (a) comprises at least 70% identity to SEQ ID NOs:
- 20, 63, 64, 65, or 66;
- (b) forms one or more amphipathic alpha-helical domains;
- and (c) has affinity to a scavenger receptor class B 1 or a portion thereof.
A targeted drug delivery vehicle composition consisting essentially of:
- a drug composition and 5-50 targeted poly-amino-acid subunits,
- wherein each of the targeted poly-amino-acid subunits comprise a targeting amino acid chain conjugated to a fatty acid, and
- wherein the targeting amino acid chain:
- (a) comprises at least 70% identity to SEQ ID NOs:
- 20, 63, 64, 65, or 66;
- (b) forms one or more amphipathic alpha-helical domains;
- (c) has affinity to a scavenger receptor class B 1 or a portion thereof;
- and (d) promotes uptake of the drug composition into a target cell.
Dependencies are inferred from the claim text.